Applications are invited for a data scientist to support a new, multi-institutional scientific program studying the flow of cerebrospinal fluid in the brain, with the hypothesis that flow is ultimately controlled by neural circuits, often via blood flow modulations. The data scientist will work as part of a Data Science Core, led by Douglas H. Kelley, Mujdat Cetin, and Jiebo Luo, all in the Hajim School of Engineering and Applied Sciences at the University of Rochester. Also employing two PhD students and part-time undergraduate researchers, the Data Core will provide integrated data storage and analysis infrastructure for the four scientific Projects and the Viral Core that together comprise the scientific program. The Data Core will also build and refine novel data analysis tools and facilitate public sharing of data and software. Diverse and large data will be produced by the Projects, including MRI imaging in humans, two-photon imaging in mice, brain-wide microscopy in mice, electrophysiological measurements in mice, vital sign measurements, computational fluid dynamics simulations, and network simulations of flow and transport through the brain. Key tasks for the data scientist include streamlining existing workflows for data pre-/post-processing and analysis, providing organized and searchable storage infrastructure, developing new statistical and machine-learning algorithms for quantitative information extraction and analysis from multi-modal brain imaging, and linking brain states to CSF flow patterns via artificial intelligence. An MS or PhD in a data-intensive field is required. Experience with imaging, large data sets, and modern AI methods is key; experience with neuroscience or other biological applications is desirable but not required.
The data scientist will enjoy excellent resources and opportunities for collaboration. The position will be affiliated with the Goergen Institute for Data Science (directed by Mujdat Cetin) and will involve frequent interactions with the Center for Integrated Research Computing, making extensive use of its BlueHive computing cluster. The data scientist will benefit from close collaborative links with the four Projects, led by Maiken Nedergaard (University of Rochester), Patrick Drew (Penn State University), Laura Lewis (Boston University), and Douglas H. Kelley. Interactions with PhD students and postdoctoral researchers in the Data Core and the Projects will be direct and frequent. Optionally, the data scientist might take on a research faculty role allowing formal mentoring of PhD students. We anticipate hiring for one year, with opportunity to renew; funds are available for four years. Longer-term career opportunities may also be available (e.g., at GIDS or CIRC).
This position will be available in early 2023. Applicants should email a curriculum vitae and cover letter.
OPENINGS: Postdoctoral Researchers
Applications are invited for multiple postdoctoral researchers to model the dynamics of cerebrospinal fluid in the brain at the University of Rochester. The work will focus on fluid flow and transport of solutes, including wastes and nutrients, in the glymphatic system, which circulates cerebrospinal fluid through the brain during sleep. That circulation has important implications for human health: diseases such as Alzheimer's and Parkinson's correlate with accumulation of brain metabolic wastes, and pathologies such as stroke and cardiac arrest involve damaging swelling caused by the inrush of cerebrospinal fluid. The postdoctoral researchers will develop high-fidelity models of local flows using direct numerical simulations and extend an existing, brain-wide hydraulic network model of the fluid pathways. They will also develop local and brain-wide models for solute transport, caused by both advection and diffusion, based on the flow models. Several related questions about brain fluid flow might also be addressed. Experience with computational fluid dynamics is key; experience with neuroscience or other biological applications is desirable but not required.
The postdoctoral researchers will join a team in the Department of Mechanical Engineering, led by Douglas H. Kelley and John H. Thomas. The researchers will benefit from close collaborative links with three experimental projects funded simultaneously, producing groundbreaking in vivo observations in both mice and humans,and led by Maiken Nedergaard, Patrick Drew, and Laura Lewis. Iterative collaboration, in which experiments inform models and models suggest new experiments, is a central goal for all. Collaboration is also encouraged with other researchers in the Department of Mechanical Engineering studying brain fluid flows, currently including one other faculty member, other postdoctoral researchers, a few PhD students, and a few undergraduate students. Further benefits will come from a Data Science Core dedicated to support the projects by providing data infrastructure, developing code, and performing analyses, led with Mujdat Cetin and Jiebo Luo. Our team has recently published in high-impact journals including Science, Nature Communications,, and Annual Review of Fluid Mechanics.
These positions are available as of fall 2022. We anticipate hiring for one year, with opportunity to renew; funds are available for five years. For full consideration, applicants should email a curriculum vitae and cover letter.
OPENING: Research Administrator
Research Administrator for two dynamic University research teams, led by Principal Investigators (PIs) Douglas H. Kelley and Ranga Dias. The Research Administrator works at the base of two vibrant and growing University teams, interacting daily with the PIs who lead the teams as well as team members, including research faculty, postdoctoral researchers, graduate students, and undergraduate researchers. Minimally, the Research Administrator takes on tasks that are necessary and important but do not require extensive scientific training, freeing the PIs to focus their expertise where it is most beneficial. Helping the PIs stay organized, helping the teams stay organized, and assisting with written communication are examples of such tasks. Ideally, the Research Administrator operates with significant autonomy and develops innovative procedures and norms to enhance scientific collaboration and efficiency among the teams. More specifics are listed below.
Provides administrative support and financial oversight of daily operations of the teams, splitting time 50/50. Supports annual NIH and NSF financial reporting as needed, including forecasting budget expenses, associated project and subaward accounting, and strategic planning. Liaison reporting with central offices to include Office of Research and Projects Administration, Office of Research Accounting and Costing Standards; National Science Foundation, and/or other partner organizations. In cooperation with staff of the Department of Mechanical Engineering, provides monthly written financial updates for each account overseen by the PIs, including encumbrances, comparing actual spending to budgets for the Center for Translational Neuroscience and Unearthly Materials, Inc. Manages expense reimbursement and purchasing process for both teams in adherence with University of Rochester and sponsor policies. In cooperation with staff of the Department of Mechanical Engineering, presents strategic financial updates in a meeting each quarter, summarizing current account balances, projecting future spending, and estimating date when each account will be empty. In cooperation with the PIs, writes supporting documents for grant proposals, e.g. biosketches / curriculum vitae, lists of current and pending support. Edits and improves language in scientific sections of proposals, as drafted by the PIs. In cooperation with the PIs and with staff of the Department of Mechanical Engineering, writes budgets for the PIs’ grant proposals. Oversees reporting requirements for grants won by the PIs, authoring or coauthoring reports with the PIs. Drafts annual Faculty Activity Reports for the PIs. Arranges travel, conference registrations, and associated logistical matters for the PIs. Manages the PIs’ work calendars. Participates in daily problem solving for operational issues of the two teams. As appropriate, alerts PIs to interpersonal challenges among the team that could compromise the collegiality, diversity, or productivity of the workplace. Maintains and updates the websites of the two research teams.
This position is available starting fall 2022. Funds are available for five years. Applications should be submitted via the University's system; search for posting number 238400.
Douglas H. Kelley is an Associate Professor of Mechanical Engineering and earned a PhD in physics from the University of Maryland. He held postdoctoral appointments at Yale University (in mechanical engineering) and Massachusetts Institute of Technology (in materials science and engineering). Previously he earned an MS from Auburn University and a BS from Virginia Tech. Doug is a member of the American Physical Society, ASME, and AAAS.
Doug's ORCiD profile | Doug's Google Scholar profile
218 Hopeman Hall
Rochester, NY 14627-0132
Aditya Raghunadnan (Adi) is a postdoctoral research associate in Mechanical Engineering at the University of Rochester. He obtained his PhD in Mechanical Engineering at Rensselaer Polytechnic Institute, working on interfacial and biological soft matter flows. Previously, Adi also earned an MS from Rose-Hulman Institute of Technology and a Bachelor's degree in Mechanical Engineering from India.
Kimberly Boster is a postdoctoral research associate in Mechanical Engineering at the University of Rochester. Prior to this she was a Lillian Gilbreth Postdoctoral Fellow at Purdue University. She obtained her PhD in Mechanical Engineering at Brigham Young University, studying phase-change heat transfer on superhydrophobic surfaces. She also earned an MS studying human vocal fold fluid-structure interactions and a Bachelor's degree in Mechanical Engineering from Brigham Young University.
Mohammad Y. Abdelshafy (Yasser) is pursuing a PhD in mechanical engineering at the University of Rochester. He obtained his bachelor’s degree in mechanical and energy engineering from Helwan University in Cairo, Egypt. There, he built an experimental setup for a solar-assisted, PVT desiccant evaporative air conditioner for the semi-arid climate of Cairo. He is also a member of the Egyptian Society for Renewable Energy (ESRE).
Yiming Gan is pursuing a PhD in Mechanical Engineering at the University of Rochester. Previously, he earned a BS degree in Mechanical Engineering at the University of Science and Technology of China.
Ruy Ibanez is pursuing a PhD in Mechanical Engineering at the University of Rochester. Prior to that he received his MSME from Baylor University and a BS in Physics at the University of Texas at Austin.