Research
Vascular Imaging
Cardiovascular disease represents a major clinical problem both here in the United States and in the rest of the world. Early detection is challenging because the disease progresses slowly and is, in many cases, asymptomatic. The goal of this research is to use ultrasound elastography to detect disease in the carotid artery of patients that are at risk of developing cardiovascular disease. Specifically, we detect vascular aging in the HIV+ population, detect subclinical atherosclerosis, and evaluate the efficacy of novel genetic and pharmacological therapies.
Journal Articles
- Natriuretic peptide receptor 2 locus contributes to carotid remodeling
V. A. Korshunov, E. M. Smolock, M. E. Wines-Samuelson, A. Faiyaz, D. M. Mickelsen, B. Quinn, C. Pan, G. J. Dugbartey, C. Yan, M. M. Doyley, A. J. Lusis, and B. C. Berk
J Am Heart Assoc 9(10) , pp. 014257-1 -014257-12 (2020). View Online - The protective role of natriuretic peptide receptor 2 against high salt injury in the renal papilla
G. J. Dugbartey, B. Quinn, L. Luo, D. M. Mickelsen, S. K. Ture, C. N. Morrell, J. Czyzyk, M. M. Doyley, C. Yan, B. C. Berk, and V. A. Korshunov
Am J Pathol 189(9) , pp. 1721 -1731 (2019). View Online - Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains
V. A. Korshunov, B. Quinn, A. Faiyaz, R. Ahmed, M. P. Snowden, M. M. Doyley, and B. C. Berk
Br J Pharmacol 176(15) , pp. 2795 -2807 (2019). View Online - Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis
M. V. Singh, S. Kotla, N. T. Le, K. A. Ko, K. S. Heo, Y. Wang, Y. Fujii, H. T. Vu, E. McBeath, T. N. Thomas, Y. J. Gi, Y. T. Tao, J. L. Medina, J. Taunton, Nancy Carson, Vikram Dogra, M. M. Doyley, A. Tyrell, W. Lu, X. Qiu, N. E. Stirpe, K. Gates, C. Hurley, K. Fujiwara, S. Maggirwar, G. Schifitto, and J. Abe
Circulation 139(9) , pp. 1199 -1216 (2019). View Online - Visualizing angle-independent principal strains in the longitudinal view of the carotid artery: phantom and in vivo evaluation
Rohit Nayak, G. Schifitto, and M. M. Doyley
Ultrasound Med BIol 44(7) , pp. 1379 -1391 (2018). View Online - Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
V. A. Korshunov, H. Wang, R. Ahmed, D. M. Mickelsen, Q. Zhou, C. Yan, and M. M. Doyley
Sci Rep 7 , pp. 12081-1 -12081-12 (2017). View Online - Noninvasive carotid artery elastography using multielement synthetic aperture imaging: phantom and in vivo validation
Rohit Nayak, G. Schifitto, and M. M. Doyley
Med Phys 44(8) , pp. 4068 -4082 (2017). View Online - Principal strain vascular elastography: simulation and preliminary clinical evaluation
Rohit Nayak, Steven Huntzicker, Jacques Ohayon, Nancy Carson, Vikram Dogra, G. Schifitto, and M. M. Doyley
Ultrasound Med Biol 43(3) , pp. 682 -699 (2017). View Online - Contrast-enhanced quantitative intravascular elastography: the impact of microvasculature on model-based elastography
Steven Huntzicker, Himanshu Shekhar, and M. M. Doyley
Ultrasound Med Biol 42(5) , pp. 1167 -1181 (2016). View Online - The imaging modulography technique revisited for high-definition intravascular ultrasound: theoretical framework
A. Tacheau, Simon Le Floc'h, Gerard Finet, M. M. Doyley, Roderic I. Pettigrew, G. Cloutier, and Jacques Ohayon
Ultrasound Med Biol 42(3) , pp. 727 -741 (2016). View Online - Axl modulates immune activation of smooth muscle cells in vein graft remodeling
S. Batchu, J. Xia, K. A. Ko, M. M. Doyley, J. Abe, C. N. Morrell, and V. A. Korshunov
Am J Physiol Heart Circ Physiol 309(6) , pp. H1048 -H1058 (2015). View Online - An intravascular coronary plaque elasticity reconstruction method using limited depth penetration ultrasound signals
A. Tacheau, Simon Le Floc'h, Gerard Finet, M. M. Doyley, Roderic I. Pettigrew, G. Cloutier, and Jacques Ohayon
Comput Methods Biomech Biomed Engin 18(Suppl 1) , pp. 2066 -2067 (2015). View Online - Visualizing the stress distribution within vascular tissues using intravascular ultrasound elastography: a preliminary investigation
Michael S. Richards, R. Perucchio, and M. M. Doyley
Ultrasound Med Biol 41(6) , pp. 1616 -1631 (2015). View Online - A new finite element method for inverse problems in structural analysis: application to atherosclerotic plaque elasticity reconstruction
Adeline Bouvier, Flavian Deleaval, M. M. Doyley, A. Tacheau, Gerard Finet, Simon Le Floc'h, G. Cloutier, Roderic I. Pettigrew, and Jacques Ohayon
Comput Methods Biomech Biomed Engin 17(Suppl 1) , pp. 16 -17 (2014). View Online - Quantitative sparse array vascular elastography: the impact of tissue attenuation and modulus contrast on performance
Steven Huntzicker, Rohit Nayak, and M. M. Doyley
Journal of Medical Imaging. Vol 1, Issue 2 , pp. 027001-1 -027001-13 (2014). View Online - A direct vulnerable atherosclerotic plaque elasticity reconstruction method based on an original material-finite element formulation: theoretical framework
Adeline Bouvier, Flavian Deleaval, M. M. Doyley, Sammi K. Yazdani, Gerard Finet, Simon Le Floc'h, G. Cloutier, Roderic I. Pettigrew, and Jacques Ohayon
Phys Med Biol 58(23) , pp. 8457 -8476 (2013). View Online - Non-Rigid Image Registration Based Strain Estimator for Intravascular Ultrasound Elastography.
Michael S. Richards and M. M. Doyley
Ultrasound in Medicine and Biology. Vol 39, Issue 3. [Epub ahead of print] (2013). View Online - Non-invasive Vascular Displacement Estimation for Relative Elastic Modulus Reconstruction in Transversal Imaging Planes.
Hendrik H. G. Hansen, Michael S. Richards, M. M. Doyley, and Chris L. de Korte
Sensors. Vol 13, Issue 3. [Epub ahead of print] (2013). View Online - Noninvasive Vascular Elastography Using Plane-Wave and Sparse-Array Imaging.
Sanghamithra Korukonda, Rohit Nayak, Nancy Carson, G. Schifitto, Vikram Dogra, and M. M. Doyley
IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control. Vol 60, Issue 2. [Epub ahead of print] (2013). View Online - Delineation of Altherosclerotic Plaque Using Subharmonic Imaging Filtering Techniques and a Commercial Intravascular Ultrasound System.
Anush Shridharan, John R. Eisenbrey, Priscilla Machado, Ebo D. deMuinck, M. M. Doyley, and Flemming Forsberg
Ultrasonic Imaging. Vol 35, Issue 1. [Epub ahead of print] (2013). View Online - Visualizing the Radial and Circumferential Strain Distribution Within Vessel Phantoms Using Synthetic-Aperture Ultrasound Elastography.
Sanghamithra Korukonda and M. M. Doyley
IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control. Vol 59, Issue 8. [Epub ahead of print]. (2012). View Online - Investigating the impact of spatial priors on the performance of model-based IVUS elastography.
Michael S. Richards and M. M. Doyley
Phys Med Biol. 2011 Oct 28;56(22) , pp. 7223 -7246 (2011). View Online - Characterization of atherosclerotic plaques and mural thrombi with intravascular ultrasound elastography: a potential method evaluated in an aortic rabbit model and a human coronary artery.
R. L. Maurice, J. Fromageau, M. H. R. Cardinal, M. M. Doyley, Ebo D. deMuinck, J. Robb, and G. Cloutier
IEEE Trans. IT in Biomedicine. 12(3). Epub 2008 May 7. , pp. 290 -298 (2008). View Online - Morphological and mechanical information of coronary arteries obtained with intravascular elastography; feasibility study in vivo.
Chris L. de Korte, S. G. Carlier, F. Mastik, M. M. Doyley, A. F. van der Steen, P. W. Serruys, and N. Bom
Eur Heart J. 23(5) , pp. 405 -413 (2002). View Online - Advancing intravascular ultrasonic palpation toward clinical applications.
M. M. Doyley, F. Mastik, Chris L. de Korte, E. I. Céspedes, P. W. Serruys, N. Bom, and A. F. van der Steen
Ultrasound Med Biol. (11) , pp. 1471 -1480 (2001). View Online