Edward Brown earned his BS with honors in physics from Wake Forest University, and his PhD in physics from Cornell University. He was a post-doctoral fellow and instructor at Massachusetts General Hospital/Harvard Medical School in the Department of Radiation Oncology before joining the University of Rochester Department of Biomedical Engineering, where he is now an associate professor with tenure. Dr. Brown's research focuses on tumor metastasis, and how it is influenced by the extracellular matrix, neuronal activity, and stress signaling. To study these phenomena he develops and uses novel optical techniques. He invented the multiphoton fluorescence recovery after photobleaching technique (Brown et al Biophys J 1999), demonstrated the first application of multiphoton laser-scanning microscopy to tumor biology (Brown et al Nat Med 2001), and pioneered the application of second harmonic generation (SHG) to study the tumor extracellular matrix (Brown et al Nat Med 2003). He developed the first technique to allow the quantification of SHG emission directionality in intact tissue (Han et al Optics Exp 2010) and demonstrated that SHG directionality predicts metastatic involvement in certain types of breast cancer (Burke et al J Biomed Opt 2013). Furthermore he demonstrated that the most prognostic information comes from the tumor/host interface, and that SHG directionality combined with a surrogate for a market leading genomic predictor provides better prognostic power than either predictor alone (Desa et al 2020) . He has been named a Pew Scholar in the biomedical sciences, a Department of Defense Breast Cancer Research Program “Era of Hope” Scholar, and an NIH Director’s New Innovator.
Our research program focuses on the application of multiphoton laser-scanning microscopy (MPLSM) to the study of biological processes in vivo, i.e. in living, intact tissue. We undertake the creation of novel MPLSM-based imaging and measurement techniques, as well as their application to the study of tumor biology in vivo, with an emphasis on the biology and biophysics of breast cancer.
- Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology