Cell & Tissue Engineering
One of the most exciting areas in biomedical engineering is tissue engineering. Tissue engineering is the ability to generate living tissue ex vivo for replacement or therapeutic applications through materials development, biochemical manipulations, cell culture, and genetic engineering.
This area of research and development has the potential to revolutionize the treatment of a wide variety of disorders and injuries.
Of fundamental importance in the design of such tissues is the ability to understand and predict how cell behavior, cell growth, and differentiation are affected by the mechanochemistry of the cellular environment. There is ample evidence showing that the physical surroundings of cells, both chemical and mechanical, can have profound effects on cellular behavior, including growth and differentiation.
Of particular importance is first understanding, then controlling, the effects of physical contacts between cells, between cells and artificial substrates, and between cells and the extracellular matrix that they produce.
Molecular, cellular and tissue engineering encompasses the study of cellular interactions using principles of engineering, physical chemistry, and physics to more clearly understand the mechanism of cellular responses to surface contacts. It includes the design of surfaces for the purpose of eliciting a particular cellular response, and it includes the application of this knowledge to generate cellular systems for therapeutics, sensors, and novel tools for research.
Example Research Projects:
|Hani A. Awad, PhD||Musculoskeletal tissue engineering|
|Danielle Benoit, PhD||Therapeutic biomaterials|
|Mark Buckley, PhD||Viscoelasticity in soft biological tissues; soft tissue aging, disease and repair|
|Patricia Chess, PhD||Effects of strain on pulmonary epithelium|
|Robert L. Clark, PhD||Dynamic systems, measurement and control, and the exploration of single-molecule mechanics|
|Diane Dalecki, PhD||Biomedical ultrasound, acoustics, lithotripsy, biological effects of ultrasound|
|David Dean, PhD||Gene therapy|
|Lisa A. DeLouise, PhD, MPD||Engineering smart bandage bio nanomaterials for healing skin|
|Angela Glading, PhD||Role of cell-cell contact in regulating cellular function in both the normal and disease state|
|Denise C. Hocking, PhD||Regulation of cell behavior by the extracellular matrix|
|Catherine K. Kuo, PhD||Tissue engineering; Orthopaedics; Stem cells; Developmental biology; Mechanobiology; Biomaterials|
|Whasil Lee, PhD||Musculoskeletal cell mechanics, mechanosensitive ion channels, knee joint tissue development, aging, disease and repair|
|Elena Lomakina, PhD||Cell adhesion, mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins|
|Anne Luebke, PhD||Role of cochlear outer hair cells in hearing and hearing loss, at both the molecular and systems levels|
|James L. McGrath, PhD||Cell motility, and quantitative light microscopy|
|Jong-Hoon Nam, PhD||Biophysics of inner ear sensory cells, cell mechanics|
|J. Edward Puzas, PhD||Molecular and cellular biology of the skeletal system|
|Ingrid H. Sarelius, PhD||Vascular cell communication and signaling|
|Edward M. Schwarz, PhD||Pro-inflammatory cytokine signal transduction and novel drug and gene therapies for Rheumatoid Arthritis.|
|Richard E. Waugh, PhD||Cell adhesion, mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins|
|David Wu, PhD||Biochemical engineering, fermentation, biocatalysis, bone marrow tissue engineering, molecular biology|
|Xinping Zhang, B.Med., Ph.D.||Skeletal repair, bone tissue engineering, bone tissue vascularization using integrated genetic, engineering, and multiphoton-based imaging approaches|