## MixingLab Publications

#### Journal papers

**Under review**

- Vital role of lymphatic vessels in eliminating post-traumatic cerebral edema and improving functional outcome. R. Hussain, J. Tithof, W. Wang, A. Cheetham-West, B. Sigurdsson, Q. Sun, S. Peng, V. Plá, D. H. Kelley, H. Hirase, J. A. Castorena-Gonzalez, S. A. Goldman, P. Weikop, M. J. Davis, and M. Nedergaard.
*Submitted.* - Artificial intelligence velocimetry reveals
*in vivo*flow rates, pressure gradients, and shear stresses in murine perivascular flows. K. A. S. Boster, S. Cai, A. Ladrón-de-Guevara, J. Sun, X. Zheng, T. Du, J. H. Thomas, M. Nedergaard, G. E. Karniadakis, and D. H. Kelley.*Submitted.* - Perivascular cerebrospinal fluid flow is the primary source of interstitial fluid in the rat brain. K. N. Mortensen, T. Lilius, M. Rosenholm, B. Sigurðsson, D. H. Kelley and M. Nedergaard.
*Submitted.* - Functional hyperemia increases glymphatic CSF influx and clearance. S. Holstein-Rønsbo, Y. Gan, M. K. Rasmussen, B. Sigurdsson, F. R. M. Beinlich, L. Hablitz, M. Giannetto, L. Rose, D. H. Kelley, and M. Nedergaard.
*Submitted.*

**2023**

- Cerebrospinal fluid flow. D. H. Kelley and J. H. Thomas.
*Annu. Rev. Fluid Mech.*2023.

**2022**

- Laboratory model of electrovortex flow with thermal gradients, for liquid metal batteries. J. S. Cheng, B. Wang, I. Mohammad, J. M. Forer, and D. H. Kelley.
*Exp. Fluids*2022. - A bioinspired apparatus for modeling peristaltic pumping in biophysical flows. R. Ibanez and D. H. Kelley.
*Bioinsp. Biomemet. 2022.* - Oscillations of the large-scale circulation in experimental liquid metal convection at aspect ratios 1.4–3. J. S. Cheng, I. Mohammad, B. Wang, D. F. Keogh, J. M. Forer, and D. H. Kelley.
*J. Fluid Mech.*2022. - A novel in vivo clearance assay for quantification of glymphatic efflux. V. Plá, P. Bork, A. Harnpramukkul, G. Olveda, R. Hussain, W. Wang, D. H. Kelley, L. M. Hablitz, and Maiken Nedergaard.
*Cell Rep.*2022. - The glymphatic system: Current understanding and modeling. T. Bohr, P. G. Hjorth, S. C. Holst, S. Hrabětová, V. Kiviniemi, T. Lilius, I. Lundgaard, K.-A. Mardal, E. A. Martens, Y. Mori, U. V. Nagerl, C. Nicholson, A. Tannenbaum, J. H. Thomas, J. Tithof, H. Benveniste, J. J. Iliff, D. H. Kelley, and M. Nedergaard.
*iScience*2022. - Sensitivity analysis on a network model of glymphatic flow. K. A. S. Boster, J. Tithof, D. D. Cook, J. H. Thomas, and D. H. Kelley.
*J. R. Soc. Interface*2022. - A network model of glymphatic flow under different experimentally-motivated parametric scenarios. J. Tithof, K. A. S. Boster, P. A. R. Bork, M. Nedergaard, J. H. Thomas, and D. H. Kelley.
*iScience*2022. - Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment. A. Ladrón-de-Guevara, J. K. Shang, M. Nedergaard, and D. H. Kelley.
*J. Theo. Bio.*2022. - Oscillating currents stabilize aluminium cells for efficient, low carbon production. I. Mohammad, M. DuPuis, P. D. Funkenbusch, and D. H. Kelley.
*JOM*2022. - A hydraulic resistance model for interstitial fluid flow in the brain. H. E. Schreder, J. Liu, D. H. Kelley, J. H. Thomas, and K. A. S. Boster.
*J. R. Soc. Interface*2022.

**2021**

- A simple analytic model for peristaltic flow and mixing. R. Ibanez, M. Shokrian Amiri, J.-H. Nam, and D. H. Kelley.
*Phys. Rev. Fluids*2021. - Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. T. Du, H. Mestre, B. T. Kress, G. Liu, A. M. Sweeney, A. J. Samson, M. K. Rasmussen, K. N. Mortensen, P. A. R. Bork, W. Peng, G. E. Olveda, L. Bashford, E. R. Toro, J. Tithof, D. H. Kelley, J. H. Thomas, P. G. Hjorth, E. A. Martens, R. I. Mehta, H. Hirase, Y. Mori, and M. Nedergaard.
*Brain*2021. - Formation of spiral waves in cylindrical containers under orbital excitation. G. M. Horstmann, S. Anders, D. H. Kelley, and T. Weier.
*J. Fluid Mech.*2021. - Brain cerebrospinal fluid flow. D. H. Kelley.
*Phys. Rev. Fluids*2021. - Microscale mechanisms of ultrasound velocity measurement in metal melts. B. Wang and D. H. Kelley.
*Flow Meas. Instrum.*2021. - Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection. A. Raghunandan, A. Ladrón-de-Guevara, J. Tithof, H. Mestre, T. Du, M. Nedergaard, J. H. Thomas, and D. H. Kelley.
*eLife*2021. - Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain. D. E. Troyetsky, J. Tithof, J. H. Thomas, and D. H. Kelley.
*Sci. Rep.*2021.

**2020**

- Surface periarterial spaces in the mouse brain are open, not porous. F. Min-Rivas, J. Liu, B. C. Martell, T. Du, H. Mestre, M. Nedergaard, J. Tithof, J. H. Thomas, and D. H. Kelley.
*J. R. Soc. Interface*2020. - Endothelial cell apicobasal polarity coordinates distinct responses to luminally versus abluminally delivered TNF-α in a microvascular mimetic. A. T. Salminen, J. Tithof, Y. Izhiman, E. A. Masters, M. C. McCloskey, T. R. Gaborski, D. H. Kelley, A. P. Pietropaoli, R. E. Waugh, and J. L. McGrath.
*Integr. Biol.*2020. - Mechanically facilitated micro‐fluid mixing in the organ of corti. M. Shokrian Amiri, C. Knox, D. H. Kelley, and J.-H. Nam.
*Sci. Rep.*2020. - Efficient autocatalytic reactive mixing and solitary chemical waves in laminar flows. T. D. Nevins, D. E. Troyetsky, and D. H. Kelley.
*Phys. Rev. Fluids*2020. - Cerebrospinal fluid influx drives acute ischemic tissue swelling. H. Mestre, T. Du, A. M. Sweeney, G. Liu, A. J. Samson, W. Peng, K. N. Mortensen, F. F. Staeger, P. Bork, L. Bashford, E. R. Toro, J. Tithof, D. H. Kelley, P. G. Hjorth, E. A. Martens, R. M. O. Solis, P. Blinder, D. Kleinfeld, H. Hirase, Y. Mori, and M. Nedergaard.
*Science*2020. With commentary.

**2019**

- Vertical shear alters chemical front speed in thin-layer flows. T. D. Nevins and D. H. Kelley.
*J. Fluid Mech.*2019. - Hydraulic resistance of perivascular spaces in the brain. J. Tithof, D. H. Kelley, H. Mestre, M. Nedergaard, and J. H. Thomas.
*Fluids Barr. CNS*2019. - Comparing free surface and interface motion in electromagnetically driven thin-layer flows. B. C. Martell, J. Tithof, and D. H. Kelley.
*Phys. Rev. Fluids*2019. - PDGF-B is required for development of the glymphatic system. A. S. Munk, W. Wang, N. B. Bèchet, A. X. Cheng, B. Sigurdsson, A. Benraiss, M. A. Mäe, B. T. Kress, D. H. Kelley, C. Betsholtz, K. Møllgârd, M. Nedergaard, and I. Lundgaard.
*Cell Rep.*2019. - Three-dimensional time-resolved trajectories from laboratory insect swarms. M. Sinhuber, K. van der Vaart, R. Ni, J. G. Puckett, D. H. Kelley, and N. T. Ouellette.
*Scientific Data*2019.

**2018**

- Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. H. Mestre, J. Tithof, T. Du, W. Song, W. Peng, A. M. Sweeney, G. Olveda, J. H. Thomas, M. Nedergaard, and D. H. Kelley.
*Nat. Commun.*2018. - Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. B. A. Plog, H. Mestre, G. Olveda, H. M. Kenney, A. Cove, K. Y. Dholakia, T. Nevins, J. Tithof, I. Lundgaard, T. Du, D. H. Kelley, and M. Nedergaard.
*JCI Insight*2018. - Three-dimensionality of one- and two-layer electromagnetically driven thin-layer flows. J. Tithof, B. Martell, and D. H. Kelley.
*Phys. Rev. Fluids.*2018. - Front tracking velocimetry in advection-reaction-diffusion systems. T. D. Nevins and D. H. Kelley.
*Chaos*2018. Supplementary Software: WithFlowRelease.zip - Fluid mechanics of liquid metal batteries. D. H. Kelley and T. Weier.
*Appl. Mech. Rev.*2018. - Competing forces in liquid metal electrodes and batteries. R. F. Ashour, D. H. Kelley, A. Salas, M. Starace, N. Weber, and T. Weier.
*J. Power Sources*2018.

**2017**

- Optimal stretching in the reacting wake of a bluff body. J. Wang, J. Tithof, T. D. Nevins, R. O. Colón, and D. H. Kelley.
*Chaos*2017. - Front tracking for quantifying advection-reaction-diffusion. T. D. Nevins and D. H. Kelley.
*Chaos*2017. Supplementary software: FrontTracking.zip - Molten amide-hydroxide-iodide electrolyte for a low-temperature sodium-based liquid metal battery. R. F. Ashour, H. Yin, T. Ouchi, D. H. Kelley, and D. R. Sadoway.
*J. Electrochem. Soc.*2017.

**2016**

- A coin vibrational motor swimming at low Reynolds number. A. C. Quillen, H. Askari, D. H. Kelley, T. Friedman, and P. W. Oakes.
*Regul. Chaot. Dyn.*2016. - Optimal stretching in advection-reaction-diffusion systems. T. D. Nevins and D. H. Kelley.
*Phys. Rev. Lett.*2016.

**2015**

- Ultrasound velocity measurement in a liquid metal electrode. A. Perez and D. H. Kelley.
*J. Visualized Exp.*2015.

**2014**

- Mixing in a liquid metal electrode. D. H. Kelley and D. R. Sadoway.
*Phys. Fluids*2014. - Searching for effective forces in laboratory insect swarms. J. G. Puckett, D. H. Kelley, and N. T. Ouellette.
*Sci. Rep.*2014.

**2013**

- Lagrangian Coherent Structures separate dynamically distinct regions in fluid flows. D. H. Kelley, M. R. Allshouse, and N. T. Ouellette.
*Phys. Rev. E.*2013.*Featured in PRE Kaleidoscope.* - Quantifying stretching and rearrangement in epithelial sheet migration. R. M. Lee, D. H. Kelley, K. N. Nordstrom, N. T. Ouellette, and W. Losert.
*New J. Phys.*2013.*Featured among the Highlights of 2013.* - Emergent dynamics of laboratory insect swarms. D. H. Kelley and N. T. Ouellette.
*Sci. Rep.*2013.*Featured by Yale News, Yale Daily News, and New Haven Register.*

**2012**

- Effects of forcing geometry on two-dimensional weak turbulence. Y. Liao, D. H. Kelley, and N. T. Ouellette.
*Phys. Rev. E*2012.

**2011**

- Spatiotemporal persistence of spectral fluxes in two-dimensional flow. D. H. Kelley and N. T. Ouellette.
*Phys. Fluids*2011. - Numerical and experimental investigations of shear-driven inertial oscillations in an Earth-like geometry. H. Matsui, M. M. Adams, D. H. Kelley, S. A. Triana, D. S. Zimmerman, B. A. Buffett, and D. P. Lathrop.
*Phys. Earth Plan. Int.*2011. - Mechanisms driving shape distortion in two-dimensional flow. A. de Chaumont Quitry, D. H. Kelley and N. T. Ouellette.
*Europhys. Lett.*2011. - Onset of three-dimensionality in electromagnetic thin-layer flows. D. H. Kelley and N. T. Ouellette.
*Phys. Fluids.*2011. - Separating stretching from folding in fluid mixing. D. H. Kelley and N. T. Ouellette.
*Nature Phys.*2011. - Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment. D. H. Kelley and N. T. Ouellette.
*Am. J. Phys.*cover with multimedia, 2011.

**2010**

- Scale-dependent statistical geometry in two-dimensional flow. S. T. Merrifield, D. H. Kelley, and N. T. Ouellette.
*Phys. Rev. Lett.*2010. - Scale-local velocity fields from particle tracking data D. H. Kelley and N. T. Ouellette.
*Chaos*2010. - Selection of inertial modes in spherical Couette flow. D. H. Kelley, S. A. Triana, D. S. Zimmerman, and D. P. Lathrop.
*Phys. Rev. E*2010.

**2008**

- Hopf bifurcations with fluctuating gain. S. A. Triana, D. H. Kelley, D. S. Zimmerman, D. R. Sisan, and D. P. Lathrop.
*Astron. Nachr.*2008.

**2007**

- Inertial waves driven by differential rotation in a planetary geometry. D. H. Kelley, S. A. Triana, D. S. Zimmerman, A. Tilgner, and D. P. Lathrop.
*Geophys. Astrophys. Fluid Dyn.*2007. - The spatial correlations of dissipation and production rates in turbulent boundary and mixing layers. J. D. Diorio, D. H. Kelley, and J. M. Wallace.
*Phys. Fluids*2007.

**2006**

- Driven inertial waves in spherical Couette flow. D. H. Kelley, S. A. Triana, D. S. Zimmerman, B. Brawn, D. P. Lathrop, and D. H. Martin.
*Chaos*2006.

#### Theses

- Ultrasound measurement in metal melts: Microscale mechanisms and improvements. B. Wang, 2022.
- Fronts and Filaments: Methods for tracking and predicting the dynamical effects of advection on excitable reactions. T. D. Nevins, 2019.
- Tackling Key Engineering Challenges in Liquid Metal Batteries: Temperature and Mass Transport. R. A. Ashour, 2018.
- Calibration of a plenoptic camera for use in three-dimensional particle tracking. R. L. Bierasinski, 2014.
- Rotating, hydromagnetic experiment modelling planetary cores. D. H. Kelley, 2009.

#### Conference proceedings

- Investigation of Echo Source and Signal Deterioration in Ultrasound Measurement of Metal Melt. B. Wang, A. Caldwell, A. Allanore, and D. H. Kelley. TMS 2022 Conference Proceedings.
- I. Mohammad, M. DuPuis, P. D. Funkenbusch, and D. H. Kelley. Stabilizing electrolysis cells with oscillating currents: Amplitude, frequency and current efficiency. TMS 2022 Conference Proceedings.
- I. Mohammad and D. H. Kelley. Stabilizing a low-dimensional model of magnetohydrodynamic instabilities in aluminum electrolysis cells. TMS 2022 Conference Proceedings.
- UDV methods for characterizing flows in liquid metal batteries. J. S. Cheng, B. Wang, I. Mohammad, G. M. Horstmann, and D. H. Kelley. Proceedings of ISUD 13, ETH Zurich, 13-15 June 2021.
- Optimal Vessel Materials for Indirect-contact Ultrasound Measurements. B. Wang and D. H. Kelley. Proceedings of ISUD 13, ETH Zurich, 13-15 June 2021.
- Convection-diffusion model of Lithium-Bismuth liquid metal batteries. R. F. Ashour and D. H. Kelley.
*Mat. Proc. Fund. 2018.*