MixingLab Publications

Journal papers

Under review

• Current-driven flow transitions in laboratory liquid metal battery models. M. Y. Abdelshafy, B. Wang, I. Mohammad, J. S. Cheng, and D. H. Kelley. Submitted.
• Arousal-induced vascular dynamics induces flow reversal of the glymphatic system. A. Ladrón-de-Guevara, H. Mestre, Y. Gan, K. Boster, E. Newbold, N. Hauglund, F. Sørensen, W. Song, T. Du, D. H. Kelley, and M. Nedergaard. Submitted.
• Perivascular cerebrospinal fluid flow is the primary source of interstitial fluid in the rat brain. K. N. Mortensen, T. Lilius, M. Rosenholm, B. Sigurðsson, D. H. Kelley and M. Nedergaard. Submitted.

2024

• Inferring in vivo murine cerebrospinal fluid flow using artificial intelligence velocimetry with moving boundaries and uncertainty quantification. J. D. Toscano, C. Wu, A. Ladrón-de-Guevara, T. Du, M. Nedergaard, D. H. Kelley, G. E. Karniadakis, K. A. S. Boster. To appear in Interface Focus.
• A brain-wide solute transport model of the glymphatic system. K. Quirk, K. A. S. Boster, J. Tithof, and D. H.Kelley. J. R. Soc. Interface 2024.
• Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage. T. Du, A. Raghunandan, H. Mestre, V. Plá, G. Liu, A. Ladrón-de-Guevara, E. Newbold, P. Tobin, D. Gahn-Martinez, S. Pattanayak, Q. Huang, W. Peng, M. Nedergaard, and D. H. Kelley. Nat. Aging 2024.
• Gaps in the wall of a perivascular space act as valves to produce a directed flow of cerebrospinal fluid: A hoop-stress model. Y. Gan, J. H. Thomas, and D. H. Kelley. J. R. Soc. Interface. 2024.
• Hydraulic resistance of three-dimensional pial perivascular spaces in the brain. K. A. S. Boster, J. Sun, J. K. Shang, D. H. Kelley, and J. H. Thomas. Fluids Barr. CNS. 2024.

2023

• Potentiating glymphatic drainage minimizes post-traumatic cerebral edema. R. Hussain, J. Tithof, W. Wang, A. Cheetham-West, W. Song, W. Peng, B. Sigurdsson, D. Kim, Q. Sun, S. Peng, V. Plá, D. H. Kelley, H. Hirase, J. A. Castorena-Gonzalez, P. Weikop, S. A. Goldman, M. J. Davis, and M. Nedergaard. Nature 2023.
• Geometry-induced rectification of looped oscillatory flows. R. Ibanez, A. Raghunandan, and D. H. Kelley. Phys. Rev. Fluids 2023.
• Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow. D. Kim, Y. Gan, M. Nedergaard, D. H. Kelley, and J. Tithof. Exp. Fluids 2023.
• Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism. Y. Gan, S. Holstein-Rønsbo, M. Nedergaard, K. A. S. Boster, J. H. Thomas, and D. H. Kelley. J. R. Soc. Interface 2023.
• Sizes and shapes of perivascular spaces surrounding murine pial arteries. N. Raicevic, J. M. Forer, A. Ladrón-de-Guevara, T. Du, M. Nedergaard, D. H. Kelley and K. Boster. Fluids Barr. CNS. 2023.
• Glymphatic influx and clearance are accelerated by neurovascular coupling. S. Holstein-Rønsbo, Y. Gan, M. K. Rasmussen, B. Sigurdsson, F. R. M. Beinlich, L. Hablitz, M. Giannetto, L. Rose, D. H. Kelley, and M. Nedergaard. Nat. Neurosci. 2023.
• Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows. K. A. S. Boster, S. Cai, A. Ladrón-de-Guevara, J. Sun, X. Zheng, T. Du, J. H. Thomas, M. Nedergaard, G. E. Karniadakis, and D. H. Kelley. Proc. Nat. Acad. Sci. 2023.
• Cerebrospinal fluid flow. D. H. Kelley and J. H. Thomas. Annu. Rev. Fluid Mech. 2023.

2022

• Laboratory model of electrovortex flow with thermal gradients, for liquid metal batteries. J. S. Cheng, I. Mohammad, B. Wang, J. M. Forer, and D. H. Kelley. Exp. Fluids 2022.
• A bioinspired apparatus for modeling peristaltic pumping in biophysical flows. R. Ibanez and D. H. Kelley. Bioinsp. Biomemet. 2022.
• Oscillations of the large-scale circulation in experimental liquid metal convection at aspect ratios 1.4–3. J. S. Cheng, I. Mohammad, B. Wang, D. F. Keogh, J. M. Forer, and D. H. Kelley. J. Fluid Mech. 2022.
• A real-time in vivo clearance assay for quantification of glymphatic efflux. V. Plá, P. Bork, A. Harnpramukkul, G. Olveda, R. Hussain, W. Wang, D. H. Kelley, L. M. Hablitz, and M. Nedergaard. Cell Rep. 2022.
• The glymphatic system: Current understanding and modeling. T. Bohr, P. G. Hjorth, S. C. Holst, S. Hrabětová, V. Kiviniemi, T. Lilius, I. Lundgaard, K.-A. Mardal, E. A. Martens, Y. Mori, U. V. Nagerl, C. Nicholson, A. Tannenbaum, J. H. Thomas, J. Tithof, H. Benveniste, J. J. Iliff, D. H. Kelley, and M. Nedergaard. iScience 2022.
• Sensitivity analysis on a network model of glymphatic flow. K. A. S. Boster, J. Tithof, D. D. Cook, J. H. Thomas, and D. H. Kelley. J. R. Soc. Interface 2022.
• A network model of glymphatic flow under different experimentally-motivated parametric scenarios. J. Tithof, K. A. S. Boster, P. A. R. Bork, M. Nedergaard, J. H. Thomas, and D. H. Kelley. iScience 2022.
• Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment. A. Ladrón-de-Guevara, J. K. Shang, M. Nedergaard, and D. H. Kelley. J. Theo. Bio. 2022.
• Oscillating currents stabilize aluminium cells for efficient, low carbon production. I. Mohammad, M. DuPuis, P. D. Funkenbusch, and D. H. Kelley. JOM 2022.
• A hydraulic resistance model for interstitial fluid flow in the brain. H. E. Schreder, J. Liu, D. H. Kelley, J. H. Thomas, and K. A. S. Boster. J. R. Soc. Interface 2022.

2021

• A simple analytic model for peristaltic flow and mixing. R. Ibanez, M. Shokrian Amiri, J.-H. Nam, and D. H. Kelley. Phys. Rev. Fluids 2021.
• Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. T. Du, H. Mestre, B. T. Kress, G. Liu, A. M. Sweeney, A. J. Samson, M. K. Rasmussen, K. N. Mortensen, P. A. R. Bork, W. Peng, G. E. Olveda, L. Bashford, E. R. Toro, J. Tithof, D. H. Kelley, J. H. Thomas, P. G. Hjorth, E. A. Martens, R. I. Mehta, H. Hirase, Y. Mori, and M. Nedergaard. Brain 2021.
• Formation of spiral waves in cylindrical containers under orbital excitation. G. M. Horstmann, S. Anders, D. H. Kelley, and T. Weier. J. Fluid Mech. 2021.
• Brain cerebrospinal fluid flow. D. H. Kelley. Phys. Rev. Fluids 2021.
• Microscale mechanisms of ultrasound velocity measurement in metal melts. B. Wang and D. H. Kelley. Flow Meas. Instrum. 2021.
• Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection. A. Raghunandan, A. Ladrón-de-Guevara, J. Tithof, H. Mestre, T. Du, M. Nedergaard, J. H. Thomas, and D. H. Kelley. eLife 2021.
• Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain. D. E. Troyetsky, J. Tithof, J. H. Thomas, and D. H. Kelley. Sci. Rep. 2021.

2020

• Surface periarterial spaces in the mouse brain are open, not porous. F. Min-Rivas, J. Liu, B. C. Martell, T. Du, H. Mestre, M. Nedergaard, J. Tithof, J. H. Thomas, and D. H. Kelley. J. R. Soc. Interface 2020.
• Endothelial cell apicobasal polarity coordinates distinct responses to luminally versus abluminally delivered TNF-α in a microvascular mimetic. A. T. Salminen, J. Tithof, Y. Izhiman, E. A. Masters, M. C. McCloskey, T. R. Gaborski, D. H. Kelley, A. P. Pietropaoli, R. E. Waugh, and J. L. McGrath. Integr. Biol. 2020.
• Mechanically facilitated micro‐fluid mixing in the organ of corti. M. Shokrian Amiri, C. Knox, D. H. Kelley, and J.-H. Nam. Sci. Rep. 2020.
• Efficient autocatalytic reactive mixing and solitary chemical waves in laminar flows. T. D. Nevins, D. E. Troyetsky, and D. H. Kelley. Phys. Rev. Fluids 2020.
• Cerebrospinal fluid influx drives acute ischemic tissue swelling. H. Mestre, T. Du, A. M. Sweeney, G. Liu, A. J. Samson, W. Peng, K. N. Mortensen, F. F. Staeger, P. Bork, L. Bashford, E. R. Toro, J. Tithof, D. H. Kelley, J. H. Thomas, P. G. Hjorth, E. A. Martens, R. I. Mehta, O. Solis, P. Blinder, D. Kleinfeld, H. Hirase, Y. Mori, and M. Nedergaard. Science 2020. With commentary.

2019

• Vertical shear alters chemical front speed in thin-layer flows. T. D. Nevins and D. H. Kelley. J. Fluid Mech. 2019.
• Hydraulic resistance of perivascular spaces in the brain. J. Tithof, D. H. Kelley, H. Mestre, M. Nedergaard, and J. H. Thomas. Fluids Barr. CNS 2019.
• Comparing free surface and interface motion in electromagnetically driven thin-layer flows. B. C. Martell, J. Tithof, and D. H. Kelley. Phys. Rev. Fluids 2019.
• PDGF-B is required for development of the glymphatic system. A. S. Munk, W. Wang, N. B. Bèchet, A. X. Cheng, B. Sigurdsson, A. Benraiss, M. A. Mäe, B. T. Kress, D. H. Kelley, C. Betsholtz, K. Møllgârd, M. Nedergaard, and I. Lundgaard. Cell Rep. 2019.
• Three-dimensional time-resolved trajectories from laboratory insect swarms. M. Sinhuber, K. van der Vaart, R. Ni, J. G. Puckett, D. H. Kelley, and N. T. Ouellette. Scientific Data 2019.

2018

• Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. H. Mestre, J. Tithof, T. Du, W. Song, W. Peng, A. M. Sweeney, G. Olveda, J. H. Thomas, M. Nedergaard, and D. H. Kelley. Nat. Commun. 2018.
• Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. B. A. Plog, H. Mestre, G. Olveda, H. M. Kenney, A. Cove, K. Y. Dholakia, T. Nevins, J. Tithof, I. Lundgaard, T. Du, D. H. Kelley, and M. Nedergaard. JCI Insight 2018.
• Three-dimensionality of one- and two-layer electromagnetically driven thin-layer flows. J. Tithof, B. Martell, and D. H. Kelley. Phys. Rev. Fluids. 2018.
• Front tracking velocimetry in advection-reaction-diffusion systems. T. D. Nevins and D. H. Kelley. Chaos 2018.
• Fluid mechanics of liquid metal batteries. D. H. Kelley and T. Weier. Appl. Mech. Rev. 2018.
• Competing forces in liquid metal electrodes and batteries. R. F. Ashour, D. H. Kelley, A. Salas, M. Starace, N. Weber, and T. Weier. J. Power Sources 2018.

2017

• Optimal stretching in the reacting wake of a bluff body. J. Wang, J. Tithof, T. D. Nevins, R. O. Colón, and D. H. Kelley. Chaos 2017.
• Front tracking for quantifying advection-reaction-diffusion. T. D. Nevins and D. H. Kelley. Chaos 2017. Supplementary software: FrontTracking.zip
• Molten amide-hydroxide-iodide electrolyte for a low-temperature sodium-based liquid metal battery. R. F. Ashour, H. Yin, T. Ouchi, D. H. Kelley, and D. R. Sadoway. J. Electrochem. Soc. 2017.

2016

• A coin vibrational motor swimming at low Reynolds number. A. C. Quillen, H. Askari, D. H. Kelley, T. Friedman, and P. W. Oakes. Regul. Chaot. Dyn. 2016.
• Optimal stretching in advection-reaction-diffusion systems. T. D. Nevins and D. H. Kelley. Phys. Rev. Lett. 2016.

2015

• Ultrasound velocity measurement in a liquid metal electrode. A. Perez and D. H. Kelley. J. Visualized Exp. 2015.

2014

• Mixing in a liquid metal electrode. D. H. Kelley and D. R. Sadoway. Phys. Fluids 2014.
• Searching for effective forces in laboratory insect swarms. J. G. Puckett, D. H. Kelley, and N. T. Ouellette. Sci. Rep. 2014.

2013

• Lagrangian Coherent Structures separate dynamically distinct regions in fluid flows. D. H. Kelley, M. R. Allshouse, and N. T. Ouellette. Phys. Rev. E. 2013. Featured in PRE Kaleidoscope.
• Quantifying stretching and rearrangement in epithelial sheet migration. R. M. Lee, D. H. Kelley, K. N. Nordstrom, N. T. Ouellette, and W. Losert. New J. Phys. 2013. Featured among the Highlights of 2013.
• Emergent dynamics of laboratory insect swarms. D. H. Kelley and N. T. Ouellette. Sci. Rep. 2013. Featured by Yale News, Yale Daily News, and New Haven Register.

2012

• Effects of forcing geometry on two-dimensional weak turbulence. Y. Liao, D. H. Kelley, and N. T. Ouellette. Phys. Rev. E 2012.

2011

• Spatiotemporal persistence of spectral fluxes in two-dimensional flow. D. H. Kelley and N. T. Ouellette. Phys. Fluids 2011.
• Numerical and experimental investigations of shear-driven inertial oscillations in an Earth-like geometry. H. Matsui, M. M. Adams, D. H. Kelley, S. A. Triana, D. S. Zimmerman, B. A. Buffett, and D. P. Lathrop. Phys. Earth Plan. Int. 2011.
• Mechanisms driving shape distortion in two-dimensional flow. A. de Chaumont Quitry, D. H. Kelley and N. T. Ouellette. Europhys. Lett. 2011.
• Onset of three-dimensionality in electromagnetic thin-layer flows. D. H. Kelley and N. T. Ouellette. Phys. Fluids. 2011.
• Separating stretching from folding in fluid mixing. D. H. Kelley and N. T. Ouellette. Nat. Phys. 2011.
• Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment. D. H. Kelley and N. T. Ouellette. Am. J. Phys. cover with multimedia, 2011.

2010

• Scale-dependent statistical geometry in two-dimensional flow. S. T. Merrifield, D. H. Kelley, and N. T. Ouellette. Phys. Rev. Lett. 2010.
• Scale-local velocity fields from particle tracking data D. H. Kelley and N. T. Ouellette. Chaos 2010.
• Selection of inertial modes in spherical Couette flow. D. H. Kelley, S. A. Triana, D. S. Zimmerman, and D. P. Lathrop. Phys. Rev. E 2010.

2008

• Hopf bifurcations with fluctuating gain. S. A. Triana, D. H. Kelley, D. S. Zimmerman, D. R. Sisan, and D. P. Lathrop. Astron. Nachr. 2008.

2007

• Inertial waves driven by differential rotation in a planetary geometry. D. H. Kelley, S. A. Triana, D. S. Zimmerman, A. Tilgner, and D. P. Lathrop. Geophys. Astrophys. Fluid Dyn. 2007.
• The spatial correlations of dissipation and production rates in turbulent boundary and mixing layers. J. D. Diorio, D. H. Kelley, and J. M. Wallace. Phys. Fluids 2007.

2006

• Driven inertial waves in spherical Couette flow. D. H. Kelley, S. A. Triana, D. S. Zimmerman, B. Brawn, D. P. Lathrop, and D. H. Martin. Chaos 2006.

Theses

• Fluid transport in oscillatory flows. R. Ibanez, 2023.
• On stabilizing aluminium electrolysis cells with oscillating currents. I. Mohammad, 2023.
• Ultrasound measurement in metal melts: Microscale mechanisms and improvements. B. Wang, 2022.
• Fronts and Filaments: Methods for tracking and predicting the dynamical effects of advection on excitable reactions. T. D. Nevins, 2019.
• Tackling Key Engineering Challenges in Liquid Metal Batteries: Temperature and Mass Transport. R. A. Ashour, 2018.
• Calibration of a plenoptic camera for use in three-dimensional particle tracking. R. L. Bierasinski, 2014.
• Rotating, hydromagnetic experiment modelling planetary cores. D. H. Kelley, 2009.

Conference proceedings

• Investigation of Echo Source and Signal Deterioration in Ultrasound Measurement of Metal Melt. B. Wang, A. Caldwell, A. Allanore, and D. H. Kelley. TMS 2022 Conference Proceedings.
• Stabilizing electrolysis cells with oscillating currents: Amplitude, frequency and current efficiency. I. Mohammad, M. DuPuis, P. D. Funkenbusch, and D. H. Kelley. TMS 2022 Conference Proceedings.
• Stabilizing a low-dimensional model of magnetohydrodynamic instabilities in aluminum electrolysis cells. I. Mohammad and D. H. Kelley. TMS 2022 Conference Proceedings.
• UDV methods for characterizing flows in liquid metal batteries. J. S. Cheng, B. Wang, I. Mohammad, G. M. Horstmann, and D. H. Kelley. Proceedings of ISUD 13, ETH Zurich, 13-15 June 2021.
• Optimal Vessel Materials for Indirect-contact Ultrasound Measurements. B. Wang and D. H. Kelley. Proceedings of ISUD 13, ETH Zurich, 13-15 June 2021.
• Convection-diffusion model of Lithium-Bismuth liquid metal batteries. R. F. Ashour and D. H. Kelley. Mat. Proc. Fund. 2018.